BDBM301023 3-(3,5-Dimethoxyphenyl)-1-methyl-1,3,4,7-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one::US10131667, Example 1::US11053246, Example 1::US9611267, Example 1

SMILES COc1cc(OC)cc(c1)N1Cc2cnc3[nH]ccc3c2N(C)C1=O

InChI Key InChIKey=SIHZJQZSPAIYMX-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 301023   

TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent
LigandPNGBDBM301023(3-(3,5-Dimethoxyphenyl)-1-methyl-1,3,4,7-tetrahydr...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent
LigandPNGBDBM301023(3-(3,5-Dimethoxyphenyl)-1-methyl-1,3,4,7-tetrahydr...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent
LigandPNGBDBM301023(3-(3,5-Dimethoxyphenyl)-1-methyl-1,3,4,7-tetrahydr...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent
LigandPNGBDBM301023(3-(3,5-Dimethoxyphenyl)-1-methyl-1,3,4,7-tetrahydr...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent
LigandPNGBDBM301023(3-(3,5-Dimethoxyphenyl)-1-methyl-1,3,4,7-tetrahydr...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent
LigandPNGBDBM301023(3-(3,5-Dimethoxyphenyl)-1-methyl-1,3,4,7-tetrahydr...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent
LigandPNGBDBM301023(3-(3,5-Dimethoxyphenyl)-1-methyl-1,3,4,7-tetrahydr...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent
LigandPNGBDBM301023(3-(3,5-Dimethoxyphenyl)-1-methyl-1,3,4,7-tetrahydr...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent
LigandPNGBDBM301023(3-(3,5-Dimethoxyphenyl)-1-methyl-1,3,4,7-tetrahydr...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent
LigandPNGBDBM301023(3-(3,5-Dimethoxyphenyl)-1-methyl-1,3,4,7-tetrahydr...)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of human FGFR1 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent
LigandPNGBDBM301023(3-(3,5-Dimethoxyphenyl)-1-methyl-1,3,4,7-tetrahydr...)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of human FGFR2 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent
LigandPNGBDBM301023(3-(3,5-Dimethoxyphenyl)-1-methyl-1,3,4,7-tetrahydr...)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of human FGFR3 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
LigandPNGBDBM301023(3-(3,5-Dimethoxyphenyl)-1-methyl-1,3,4,7-tetrahydr...)
Affinity DataIC50: 452nMAssay Description:Inhibition of human recombinant N-terminal His6-tagged VEGFR2 expressed in baculovirus infected Sf21insect cells using biotin-labeled EQEDEPEGDYFEWLE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM301023(3-(3,5-Dimethoxyphenyl)-1-methyl-1,3,4,7-tetrahydr...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed