BDBM300958 US10131663, Example 24

SMILES C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@H](N1C[C@@](C)(F)CO)c1c(F)cc(NC2CN(CCCF)C2)cc1F

InChI Key InChIKey=HZEJTMIZKGGUNU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 300958   

TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM300958(US10131663, Example 24)
Affinity DataIC50: 10nMAssay Description:The assay principle is that ER alpha-LBD (GST) is added to a fluorescent ligand to form a receptor/fluorophore complex. A terbium-labelled anti-GST a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
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TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM300958(US10131663, Example 24)
Affinity DataIC50: 0.210nMAssay Description:The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
Go to US Patent