BDBM300879 (3R)-3-(6-((3-(4-(2- Methoxyethoxy)-2- methylphenyl) benzo[b]thiophen-5- yl)methoxy)pyridin-3-yl) hex-4-ynoic acid::US10131648, Compound 77::US10195178, Compound 77::US9790198, Compound 77

SMILES COCCOc1ccc(-c2csc3ccc(COc4ccc(cn4)[C@H](CC(O)=O)C#CC)cc23)c(C)c1

InChI Key InChIKey=SJMCOJMOWSZKOY-UHFFFAOYSA-N

Data  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 300879   

TargetFree fatty acid receptor 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM300879((3R)-3-(6-((3-(4-(2- Methoxyethoxy)-2- methylpheny...)
Affinity DataEC50:  9nMAssay Description:Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
Go to US Patent

TargetFree fatty acid receptor 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM300879((3R)-3-(6-((3-(4-(2- Methoxyethoxy)-2- methylpheny...)
Affinity DataEC50:  16nMAssay Description:Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetFree fatty acid receptor 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM300879((3R)-3-(6-((3-(4-(2- Methoxyethoxy)-2- methylpheny...)
Affinity DataEC50:  5nMAssay Description:Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetFree fatty acid receptor 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM300879((3R)-3-(6-((3-(4-(2- Methoxyethoxy)-2- methylpheny...)
Affinity DataEC50:  16nMAssay Description:Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
Go to US Patent

TargetFree fatty acid receptor 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM300879((3R)-3-(6-((3-(4-(2- Methoxyethoxy)-2- methylpheny...)
Affinity DataEC50:  6nMAssay Description:Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
Go to US Patent

TargetFree fatty acid receptor 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM300879((3R)-3-(6-((3-(4-(2- Methoxyethoxy)-2- methylpheny...)
Affinity DataEC50:  5nMAssay Description:Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
Go to US Patent