BDBM300866 3-(6-((3-(2-Methyl-4-((3- methyl-1,1-dioxidothietan-3- yl)methoxy)phenyl)benzo[b] thiophen-5-yl)methoxy)pyridin-3- yl)hex-4-ynoic acid::US10131648, Compound 64::US10195178, Compound 64::US9790198, Compound 64

SMILES CC#CC(CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccc(OCC5(C)CS(=O)(=O)C5)cc4C)c3c2)nc1

InChI Key InChIKey=XEQNPSYKLNQDHY-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 300866   

TargetFree fatty acid receptor 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM300866(3-(6-((3-(2-Methyl-4-((3- methyl-1,1-dioxidothieta...)
Affinity DataEC50:  21nMAssay Description:Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
Go to US Patent

TargetFree fatty acid receptor 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM300866(3-(6-((3-(2-Methyl-4-((3- methyl-1,1-dioxidothieta...)
Affinity DataEC50:  21nMAssay Description:Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetFree fatty acid receptor 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM300866(3-(6-((3-(2-Methyl-4-((3- methyl-1,1-dioxidothieta...)
Affinity DataEC50:  21nMAssay Description:Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
Go to US Patent