BDBM300634 6-(2-fluorophenyl)-N-[3-{[2-(8- oxa-3-azabicyclo[3.2.1]oct-3- yl)propanoyl]amino}-4- (trifluoromethoxy)phenyl] nicotinamide::US10130633, Example 204::US10130633, Example 205

SMILES CC(N1CC2CCC(C1)O2)C(=O)Nc1cc(NC(=O)c2ccc(nc2)-c2ccccc2F)ccc1OC(F)(F)F

InChI Key InChIKey=LMVNIXQGKHQJFM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 300634   

TargetProtein Wnt-3a(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM300634(6-(2-fluorophenyl)-N-[3-{[2-(8- oxa-3-azabicyclo[3...)
Affinity DataIC50: 76.5nMAssay Description:In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
Go to US Patent

TargetProtein Wnt-3a(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM300634(6-(2-fluorophenyl)-N-[3-{[2-(8- oxa-3-azabicyclo[3...)
Affinity DataIC50: 3.28E+4nMAssay Description:In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
Go to US Patent

TargetProtein Wnt-3a(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM300634(6-(2-fluorophenyl)-N-[3-{[2-(8- oxa-3-azabicyclo[3...)
Affinity DataIC50: 20.2nMAssay Description:In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
Go to US Patent

TargetProtein Wnt-3a(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM300634(6-(2-fluorophenyl)-N-[3-{[2-(8- oxa-3-azabicyclo[3...)
Affinity DataIC50: 1.82E+4nMAssay Description:In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
Go to US Patent