BDBM300564 4-(cyclopropyloxy)-N-[6-(2-fluorophenyl)pyridin-3-yl]-3-({[1-(morpholin-4-yl)cyclopropyl]carbonyl}amino)benzamide::US10130633, Example 134

SMILES O=C(Nc2ccc(c1ccccc1F)nc2)c6ccc(OC3CC3)c(NC(=O)C5(N4CCOCC4)CC5)c6

InChI Key InChIKey=OTOQGUOSYIPQCP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 300564   

TargetProtein Wnt-3a(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM300564(4-(cyclopropyloxy)-N-[6-(2-fluorophenyl)pyridin-3-...)
Affinity DataIC50: 16.6nMAssay Description:In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
Go to US Patent

TargetProtein Wnt-3a(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM300564(4-(cyclopropyloxy)-N-[6-(2-fluorophenyl)pyridin-3-...)
Affinity DataIC50: 5.20E+3nMAssay Description:In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
Go to US Patent

TargetProtein Wnt-3a(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM300564(4-(cyclopropyloxy)-N-[6-(2-fluorophenyl)pyridin-3-...)
Affinity DataIC50: 31nMAssay Description:In preparation of the assay, the two cell lines were plated 24 hours before beginning the test at 10000 cells per well in a 384 micro titre plate (MT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
Go to US Patent

TargetProtein Wnt-3a(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM300564(4-(cyclopropyloxy)-N-[6-(2-fluorophenyl)pyridin-3-...)
Affinity DataIC50: 1.20E+4nMAssay Description:HEK293 cells were cotransfected with the FOP control vector and pcDNA3. The FOP vector is identical to the TOP construct, but it contains instead of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
Go to US Patent