BDBM3003 1,3-diphenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine::1,3-diphenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine (11)::CHEMBL122243::pyrazolopyrimidine deriv. 1

SMILES Nc1ncnc2n(nc(-c3ccccc3)c12)-c1ccccc1

InChI Key InChIKey=CGWOMXNQGSNOHL-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 3003   

TargetEpidermal growth factor receptor(Human)
Novartis Pharmaceuticals

LigandPNGBDBM3003(1,3-diphenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine |...)
Affinity DataIC50: 800nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2005
Entry Details Article
PubMed
TargetTyrosine-protein kinase transforming protein Abl(Abelson murine leukemia virus)
Novartis Pharmaceuticals

LigandPNGBDBM3003(1,3-diphenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine |...)
Affinity DataIC50: 1.00E+4nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2005
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Novartis Pharmaceuticals

LigandPNGBDBM3003(1,3-diphenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine |...)
Affinity DataIC50: 1.00E+4nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2005
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Bovine)
Novartis Pharmaceuticals

LigandPNGBDBM3003(1,3-diphenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine |...)
Affinity DataIC50: 1.00E+5nMpH: 7.5Assay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2005
Entry Details Article
PubMed
TargetPhospholipase D1(Human)
University of Massachusetts Boston

LigandPNGBDBM3003(1,3-diphenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine |...)
Affinity DataIC50: 1.25E+3nMT: 2°CAssay Description:PLD enzymes (50 nM) were reconstituted with phospholipid vesicle substrates. All assays were performed at 37 C with agitation for 30 min. Reactions...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2014
Entry Details Article
PubMed
TargetPhospholipase D2(Human)
University of Massachusetts Boston

LigandPNGBDBM3003(1,3-diphenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine |...)
Affinity DataIC50: 1.05E+3nMT: 2°CAssay Description:PLD enzymes (50 nM) were reconstituted with phospholipid vesicle substrates. All assays were performed at 37 C with agitation for 30 min. Reactions...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2014
Entry Details Article
PubMed
TargetPhospholipase D(Streptomyces sp. PMF)
University of Massachusetts Boston

LigandPNGBDBM3003(1,3-diphenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine |...)
Affinity DataIC50: 700nMT: 2°CAssay Description:PLD enzymes (50 nM) were reconstituted with phospholipid vesicle substrates. All assays were performed at 37 C with agitation for 30 min. Reactions...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2014
Entry Details Article
PubMed
TargetPhospholipase D(Streptomyces chromofuscus)
Roxbury Community College

LigandPNGBDBM3003(1,3-diphenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine |...)
Affinity DataIC50: 1.25E+3nMpH: 8.0Assay Description:A NaOH stock solution (50 mM) was standardized with KHP then diluted in Millipore water (10-fold serial dilutions) then used to hold the pH constant ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Chicken)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM3003(1,3-diphenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine |...)
Affinity DataIC50: 500nMAssay Description:Inhibition of protein tyrosine kinase c-SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Novartis Pharmaceuticals

LigandPNGBDBM3003(1,3-diphenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine |...)
Affinity DataIC50: 501nMAssay Description:Inhibition of c-SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed