BDBM300238 US9593127, Example 12::[3-[2-(m-tolyl)ethynyl]- 3a,4,5,6a- tetrahydropyrrolo[3,2- d]isoxazol-6-yl]-(1- piperidyl)methanone

SMILES Cc1cccc(c1)C#CC1=NOC2C1CCN2C(=O)N1CCCCC1

InChI Key InChIKey=CZDHIOSRCRPHPR-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 300238   

TargetMetabotropic glutamate receptor 5(Human)
Recordati Ireland

US Patent
LigandPNGBDBM300238([3-[2-(m-tolyl)ethynyl]- 3a,4,5,6a- tetrahydropyrr...)
Affinity DataIC50: 10.6nMAssay Description:Affinity at transmembrane glutamate metabotropic mGluR5 receptor subtypes was evaluated according to the methods of Anderson (Anderson et al., J Phar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2019
Entry Details
Go to US Patent