BDBM299197 2-(4-((1H-Indazol-5-yl)amino)pyrimidin-2-yl)isoindoline-5-carbonitrile::US10125144, Example 26

SMILES N#Cc1ccc2CN(Cc2c1)c1nccc(Nc2ccc3[nH]ncc3c2)n1

InChI Key InChIKey=FZQXXCJSMIFHMF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 299197   

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandPNGBDBM299197(US10125144, Example 26 | 2-(4-((1H-Indazol-5-yl)am...)
Affinity DataIC50: 123nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1(Human)
Kadmon

US Patent
LigandPNGBDBM299197(US10125144, Example 26 | 2-(4-((1H-Indazol-5-yl)am...)
Affinity DataIC50: 1.00E+4nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
Go to US Patent