BDBM299194 (KL-00254) N-(1H-Indazol-5-yl)-2-(5-methoxyisoindolin-2-yl)-6-methyl-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-amine::US10125144, Example 22

SMILES COc1ccc2CN(Cc2c1)c1nc2CNCc2c(Nc2ccc3[nH]ncc3c2)n1

InChI Key InChIKey=XQODHURMSZBEGF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 299194   

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandPNGBDBM299194(US10125144, Example 22 | (KL-00254) N-(1H-Indazol-...)
Affinity DataIC50: 2.43E+4nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1(Human)
Kadmon

US Patent
LigandPNGBDBM299194(US10125144, Example 22 | (KL-00254) N-(1H-Indazol-...)
Affinity DataIC50: 3.50E+3nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandPNGBDBM299194(US10125144, Example 22 | (KL-00254) N-(1H-Indazol-...)
Affinity DataIC50: 2.40E+4nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1(Human)
Kadmon

US Patent
LigandPNGBDBM299194(US10125144, Example 22 | (KL-00254) N-(1H-Indazol-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
Go to US Patent