BDBM299192 2-(5-Methoxyisoindolin-2-yl)-N-(4-(pyridin-4-yl)phenyl)pyrimidin-4-amine::US10125144, Example 20::US11311541, Example 200

SMILES COc1ccc2CN(Cc2c1)c1nccc(Nc2ccc(cc2)-c2ccncc2)n1

InChI Key InChIKey=IWWPOKDCCFPYFJ-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 299192   

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandPNGBDBM299192(US10125144, Example 20 | 2-(5-Methoxyisoindolin-2-...)
Affinity DataIC50: 35nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1(Human)
Kadmon

US Patent
LigandPNGBDBM299192(US10125144, Example 20 | 2-(5-Methoxyisoindolin-2-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandPNGBDBM299192(US10125144, Example 20 | 2-(5-Methoxyisoindolin-2-...)
Affinity DataIC50: 40nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1(Human)
Kadmon

US Patent
LigandPNGBDBM299192(US10125144, Example 20 | 2-(5-Methoxyisoindolin-2-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandPNGBDBM299192(US10125144, Example 20 | 2-(5-Methoxyisoindolin-2-...)
Affinity DataIC50: 35nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1(Human)
Kadmon

US Patent
LigandPNGBDBM299192(US10125144, Example 20 | 2-(5-Methoxyisoindolin-2-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandPNGBDBM299192(US10125144, Example 20 | 2-(5-Methoxyisoindolin-2-...)
Affinity DataIC50: 40nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1(Human)
Kadmon

US Patent
LigandPNGBDBM299192(US10125144, Example 20 | 2-(5-Methoxyisoindolin-2-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandPNGBDBM299192(US10125144, Example 20 | 2-(5-Methoxyisoindolin-2-...)
Affinity DataIC50: 35nMAssay Description:Inhibition of GST-tagged recombinant human ROCK2 catalytic domain expressed in insect cells using KKRPQRRYSNVF peptide as substrate incubated for 1 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetRho-associated protein kinase 1(Human)
Kadmon

US Patent
LigandPNGBDBM299192(US10125144, Example 20 | 2-(5-Methoxyisoindolin-2-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GST-tagged recombinant human ROCK1 (1 to 535 residues) expressed in insect cells using KKRPQRRYSNVF peptide as substrate incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandPNGBDBM299192(US10125144, Example 20 | 2-(5-Methoxyisoindolin-2-...)
Affinity DataIC50: 35nMAssay Description:Inhibition of ROCK2 (unknown origin) using KKRPQRRYSNVF as substrate preincubated for 1 hrs followed by substrate addition and measured after 1 hrs i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetRho-associated protein kinase 1(Human)
Kadmon

US Patent
LigandPNGBDBM299192(US10125144, Example 20 | 2-(5-Methoxyisoindolin-2-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ROCK1 (unknown origin) using KKRPQRRYSNVF as substrate preincubated for 1 hrs followed by substrate addition and measured after 1 hrs i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed