BDBM299188 N-(2-(5-Methoxyisoindolin-2-yl)-5,6-dimethylpyrimidin-4-yl)-1H-indazol-5-amine::US10125144, Example 16::US11311541, Example 196

SMILES COc1ccc2CN(Cc2c1)c1nc(C)c(C)c(Nc2ccc3[nH]ncc3c2)n1

InChI Key InChIKey=HMBLRMRHRLWHSV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 299188   

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandPNGBDBM299188(US10125144, Example 16 | N-(2-(5-Methoxyisoindolin...)
Affinity DataIC50: 10nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandPNGBDBM299188(US10125144, Example 16 | N-(2-(5-Methoxyisoindolin...)
Affinity DataIC50: 10nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent