BDBM299186 N-(6-(5-Methoxyisoindolin-2-yl)-2-methylpyrimidin-4-yl)-1H-indazol-5-amine::US10125144, Example 14::US11311541, Example 194

SMILES COc1ccc2CN(Cc2c1)c1cc(Nc2ccc3[nH]ncc3c2)nc(C)n1

InChI Key InChIKey=RTCSLRZQDKWXOB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 299186   

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandPNGBDBM299186(US10125144, Example 14 | N-(6-(5-Methoxyisoindolin...)
Affinity DataIC50: 155nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1(Human)
Kadmon

US Patent
LigandPNGBDBM299186(US10125144, Example 14 | N-(6-(5-Methoxyisoindolin...)
Affinity DataIC50: 1.00E+4nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandPNGBDBM299186(US10125144, Example 14 | N-(6-(5-Methoxyisoindolin...)
Affinity DataIC50: 155nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1(Human)
Kadmon

US Patent
LigandPNGBDBM299186(US10125144, Example 14 | N-(6-(5-Methoxyisoindolin...)
Affinity DataIC50: 1.00E+4nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent