BDBM299179 N-(1H-Indazol-5-yl)-2-(5-methoxyisoindolin-2-yl)-5,7-dihydrofuro[3,4-d]pyrimidin-4-amine::US10125144, Example 7::US11311541, Example 187

SMILES COc1ccc2CN(Cc2c1)c1nc2COCc2c(Nc2ccc3[nH]ncc3c2)n1

InChI Key InChIKey=WYHSQTHRNOGOMH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 299179   

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandPNGBDBM299179(US10125144, Example 7 | N-(1H-Indazol-5-yl)-2-(5-m...)
Affinity DataIC50: 10nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1(Human)
Kadmon

US Patent
LigandPNGBDBM299179(US10125144, Example 7 | N-(1H-Indazol-5-yl)-2-(5-m...)
Affinity DataIC50: 3.75E+3nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandPNGBDBM299179(US10125144, Example 7 | N-(1H-Indazol-5-yl)-2-(5-m...)
Affinity DataIC50: 10nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1(Human)
Kadmon

US Patent
LigandPNGBDBM299179(US10125144, Example 7 | N-(1H-Indazol-5-yl)-2-(5-m...)
Affinity DataIC50: 3.75E+3nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent