BDBM299155 (6S,8R)-6-(2,6- difluoro-4-(2-(3- (fluoromethyl) azetidin-1- yl)ethoxy) phenyl)-1- fluoro-7- isobutyl-8- methyl-6,7,8,9- tetrahydro-3H- pyrazolo[4,3- f]isoquinoline::US10125135, Example 44

SMILES CC(C)CN1[C@H](C)Cc2c(ccc3[nH]nc(F)c23)[C@H]1c1c(F)cc(OCCN2CC(CF)C2)cc1F

InChI Key InChIKey=CIJCQUOPULFZJT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 299155   

TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM299155(US10125135, Example 44 | (6S,8R)-6-(2,6- difluoro-...)
Affinity DataIC50: 2.5nMAssay Description:The ability of compounds to bind to isolated Estrogen Receptor Alpha Ligand binding domain (ER alpha LBD (GST)) was assessed in competition assays us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
US Patent