BDBM29896 1,7-naphthyridine-3-carbonitrile, 1::CHEMBL197538

SMILES Fc1ccc(Nc2c(cnc3cnc(NCCN4CCOCC4)cc23)C#N)cc1Cl

InChI Key InChIKey=IXQLEZDNYJWUTR-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 29896   

LigandPNGBDBM29896(CHEMBL197538 | 1,7-naphthyridine-3-carbonitrile, 1)
Affinity DataIC50: 1.20E+3nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2009
Entry Details Article
PubMed
LigandPNGBDBM29896(CHEMBL197538 | 1,7-naphthyridine-3-carbonitrile, 1)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibitory activity against human Tpl2 kinase via quantification of MEK phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM29896(CHEMBL197538 | 1,7-naphthyridine-3-carbonitrile, 1)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibitory activity against SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM29896(CHEMBL197538 | 1,7-naphthyridine-3-carbonitrile, 1)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM29896(CHEMBL197538 | 1,7-naphthyridine-3-carbonitrile, 1)
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibitory activity against MK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM29896(CHEMBL197538 | 1,7-naphthyridine-3-carbonitrile, 1)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of Tpl2 kinase by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed