BDBM298321 (R)-3-[N-(3′-Chlorobiphenyl-4-ylmethyl)-N′-oxalythydrazino]-2-hydroxypropionic Acid::US10123984, Example 13::US10744104, Example 13::US20230285340, Example 13

SMILES O[C@H](CN(Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)C(O)=O)C(O)=O

InChI Key InChIKey=JYQAYNBQWZLMHO-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 298321   

TargetNeprilysin(Human)
Theravance Biopharma R&D Ip

US Patent
LigandPNGBDBM298321(US10123984, Example 13 | (R)-3-[N-(3′-Chloro...)
Affinity DataKi:  3.55nMAssay Description:The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
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TargetNeprilysin(Human)
Theravance Biopharma R&D Ip

US Patent
LigandPNGBDBM298321(US10123984, Example 13 | (R)-3-[N-(3′-Chloro...)
Affinity DataKi:  3.55nMAssay Description:The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2021
Entry Details
Go to US Patent

TargetNeprilysin/Angiotensin-converting enzyme(Human)
Theravance Biopharma R&D Ip

US Patent
LigandPNGBDBM298321(US10123984, Example 13 | (R)-3-[N-(3′-Chloro...)
Affinity DataKi:  5.5nMAssay Description:Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
Go to US Patent