BDBM29756 CHEMBL403429::hydroxyethylamine derivative, 6

SMILES CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F)N1CCCC1=O

InChI Key InChIKey=QPGDTFHILHXFBQ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 29756   

TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM29756(CHEMBL403429 | hydroxyethylamine derivative, 6)
Affinity DataIC50: 49nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandPNGBDBM29756(CHEMBL403429 | hydroxyethylamine derivative, 6)
Affinity DataIC50: 4.49E+3nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Gsk

LigandPNGBDBM29756(CHEMBL403429 | hydroxyethylamine derivative, 6)
Affinity DataIC50: 6.58E+3nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM29756(CHEMBL403429 | hydroxyethylamine derivative, 6)
Affinity DataIC50: 200nMAssay Description:Inhibition of BACE1 assessed as beta amyloid 42 production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM29756(CHEMBL403429 | hydroxyethylamine derivative, 6)
Affinity DataIC50: 40nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM29756(CHEMBL403429 | hydroxyethylamine derivative, 6)
Affinity DataIC50: 180nMAssay Description:Inhibition of BACE1 assessed as beta amyloid 40 production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandPNGBDBM29756(CHEMBL403429 | hydroxyethylamine derivative, 6)
Affinity DataIC50: 4.07E+3nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Gsk

LigandPNGBDBM29756(CHEMBL403429 | hydroxyethylamine derivative, 6)
Affinity DataIC50: 5.75E+3nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed