BDBM297546 US10118902, Example 48::US10584103, Example 48::[4-(2-methoxy-phenyl)-piperidin- 1-yl]-2-(1-trifluoromethyl- cyclopropyl)-quinazolin-6-yl]- methyl-(2-morpholin-4-yl-ethyl)- amine

SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)CCN1CCOCC1)C1(CC1)C(F)(F)F

InChI Key InChIKey=AVDOHJZYWMIILQ-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 297546   

TargetNeurotensin receptor type 1(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM297546(US10118902, Example 48 | [4-(2-methoxy-phenyl)-pip...)
Affinity DataEC50:  6.00E+3nMAssay Description:NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
Go to US Patent

TargetNeurotensin receptor type 1(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM297546(US10118902, Example 48 | [4-(2-methoxy-phenyl)-pip...)
Affinity DataEC50:  6.00E+3nMAssay Description:NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
Go to US Patent

TargetNeurotensin receptor type 1(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM297546(US10118902, Example 48 | [4-(2-methoxy-phenyl)-pip...)
Affinity DataEC50:  3.81E+3nMAssay Description:Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated be...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed