BDBM297531 N-(2-methoxyethyl)-4-(4-(2- methoxyphenyl)piperidin-1-yl)- N-methyl-2-(1- methylcyclopropyl)quinazolin- 6-amine::US10118902, Example 33::US10584103, Example 33

SMILES COCCN(C)c1ccc2nc(nc(N3CCC(CC3)c3ccccc3OC)c2c1)C1(C)CC1

InChI Key InChIKey=FNMIBFMZPJXUSK-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 297531   

TargetNeurotensin receptor type 1(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM297531(US10118902, Example 33 | N-(2-methoxyethyl)-4-(4-(...)
Affinity DataEC50:  6.00E+3nMAssay Description:NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
Go to US Patent

TargetNeurotensin receptor type 1(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM297531(US10118902, Example 33 | N-(2-methoxyethyl)-4-(4-(...)
Affinity DataEC50:  6.00E+3nMAssay Description:NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
Go to US Patent

TargetNeurotensin receptor type 1(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM297531(US10118902, Example 33 | N-(2-methoxyethyl)-4-(4-(...)
Affinity DataEC50:  2.23E+3nMAssay Description:Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated be...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed