BDBM296597 4-(6-(6-(4- (difluoromethoxy) benzyl)-3,6- diazabicyclo[3.1.1] heptan-3-yl)pyridin-3- yl)-6-(2-hydroxy-2- methylpropoxy) pyrazolo[1,5-a]pyridine-3- carbonitrile::US10112942, Example 331::US10137124, Example 331::US10172851, Example 331::US10555944, Example 331::US10953005, Example 331

SMILES CC(C)(O)COc1cc(-c2ccc(nc2)N2CC3CC(C2)N3Cc2ccc(OC(F)F)cc2)c2c(cnn2c1)C#N

InChI Key InChIKey=HJNQCCZFIIUYIE-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 296597   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM296597(US10112942, Example 331 | 4-(6-(6-(4- (difluoromet...)
Affinity DataIC50: 9.40nMpH: 7.4Assay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
Go to US Patent

LigandPNGBDBM296597(US10112942, Example 331 | 4-(6-(6-(4- (difluoromet...)
Affinity DataIC50: 30.8nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM296597(US10112942, Example 331 | 4-(6-(6-(4- (difluoromet...)
Affinity DataIC50: 9.40nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
Go to US Patent

LigandPNGBDBM296597(US10112942, Example 331 | 4-(6-(6-(4- (difluoromet...)
Affinity DataIC50: 30.8nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
Go to US Patent

LigandPNGBDBM296597(US10112942, Example 331 | 4-(6-(6-(4- (difluoromet...)
Affinity DataIC50: 9.40nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

LigandPNGBDBM296597(US10112942, Example 331 | 4-(6-(6-(4- (difluoromet...)
Affinity DataIC50: 30.8nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

LigandPNGBDBM296597(US10112942, Example 331 | 4-(6-(6-(4- (difluoromet...)
Affinity DataIC50: 9.40nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
Go to US Patent

LigandPNGBDBM296597(US10112942, Example 331 | 4-(6-(6-(4- (difluoromet...)
Affinity DataIC50: 30.8nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM296597(US10112942, Example 331 | 4-(6-(6-(4- (difluoromet...)
Affinity DataIC50: 9.40nMAssay Description:RET: Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
Go to US Patent

LigandPNGBDBM296597(US10112942, Example 331 | 4-(6-(6-(4- (difluoromet...)
Affinity DataIC50: 30.8nMAssay Description:RET: Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
Go to US Patent