BDBM29588 CHEMBL226779::isatin Michael acceptor (IMA) analogue, 3

SMILES O=[#6]1-[#7](-[#6]-c2ccccc2)-c2ccc(cc2\[#6]-1=[#6](\C#N)C#N)S(=O)(=O)[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6]-[#8]-c1ccccc1

InChI Key InChIKey=MMRPHILJDIGFET-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 29588   

TargetCaspase-6(Human)
Washington University

LigandPNGBDBM29588(CHEMBL226779 | isatin Michael acceptor (IMA) analo...)
Affinity DataIC50: 918nMAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM29588(CHEMBL226779 | isatin Michael acceptor (IMA) analo...)
Affinity DataIC50: 27.8nMAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetCaspase-6(Human)
Washington University

LigandPNGBDBM29588(CHEMBL226779 | isatin Michael acceptor (IMA) analo...)
Affinity DataIC50: 918nMAssay Description:Inhibition of human recombinant caspase 6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCaspase-8(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM29588(CHEMBL226779 | isatin Michael acceptor (IMA) analo...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human recombinant caspase 8More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM29588(CHEMBL226779 | isatin Michael acceptor (IMA) analo...)
Affinity DataIC50: 6.22E+3nMAssay Description:Inhibition of human recombinant caspase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM29588(CHEMBL226779 | isatin Michael acceptor (IMA) analo...)
Affinity DataIC50: 27.8nMAssay Description:Inhibition of human recombinant caspase 3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCaspase-7(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM29588(CHEMBL226779 | isatin Michael acceptor (IMA) analo...)
Affinity DataIC50: 51.7nMAssay Description:Inhibition of human recombinant caspase 7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed