BDBM295755 US10112935, Compound 35E

SMILES CC(C(=O)Nc1cccc(c1)-c1nnc(Nc2ccc3[nH]ncc3c2Cl)s1)c1ccc(F)cc1

InChI Key InChIKey=ZMQZOSZPBAUNFK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 295755   

TargetRho-associated protein kinase 1(Human)
Lycera

US Patent
LigandPNGBDBM295755(US10112935, Compound 35E)
Affinity DataIC50: 8.00E+3nMT: 2°CAssay Description:Assays for ROCK inhibition were performed using the following protein constructs: glutathione S-transferase (GST)-tagged human ROCK1 catalytic domain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Lycera

US Patent
LigandPNGBDBM295755(US10112935, Compound 35E)
Affinity DataIC50: 1.00E+3nMT: 2°CAssay Description:Assays for ROCK inhibition were performed using the following protein constructs: glutathione S-transferase (GST)-tagged human ROCK1 catalytic domain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
Go to US Patent