BDBM2950 6-amino-4-(3-methylbut-1-yn-1-yl)-4-(trifluoromethyl)-2,4-dihydro-1H-3,1-benzoxazin-2-one::Benzoxazinone deriv. 6d::CHEMBL111001

SMILES CC(C)C#CC1(OC(=O)Nc2ccc(N)cc12)C(F)(F)F

InChI Key InChIKey=MCBQSTBDECWUHM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 2950   

TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Dupont Pharmaceuticals

LigandPNGBDBM2950(6-amino-4-(3-methylbut-1-yn-1-yl)-4-(trifluorometh...)
Affinity DataIC50: 896nMpH: 8.2 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2004
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
S.G.S.I.T.S.

Curated by ChEMBL
LigandPNGBDBM2950(6-amino-4-(3-methylbut-1-yn-1-yl)-4-(trifluorometh...)
Affinity DataIC50: 896nMAssay Description:Inhibitory activity against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed