BDBM294415 US9586959, Compound 93

SMILES CNC1CN(C1)c1nc2ncc(Cl)cc2n2nnnc12

InChI Key InChIKey=GDZLFSXESWAMER-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 294415   

TargetHistamine H4 receptor(Human)
C&C Research Laboratories

US Patent
LigandPNGBDBM294415(US9586959, Compound 93)
Affinity DataIC50: 65nMpH: 7.5 T: 2°CAssay Description:In vitro profiling protein kinases was performed using the HotSpot assay platform. Briefly, specific kinase/substrate pairs along with required cofac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
Go to US Patent

TargetHistamine H3 receptor(Human)
C&C Research Laboratories

US Patent
LigandPNGBDBM294415(US9586959, Compound 93)
Affinity DataIC50: 1.00E+8nMpH: 7.4 T: 2°CAssay Description:Each compound of the present invention prepared in the examples was prepared in DMSO into concentrations of 0.02, 0.06, 0.3 and 2 mM. 10 uL of the pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 3A(Human)
C&C Research Laboratories

US Patent
LigandPNGBDBM294415(US9586959, Compound 93)
Affinity DataIC50: 1.00E+7nMAssay Description:The binding assays of the human serotonin 3 receptor for present invention were performed at Cerep (Poitiers, France).More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
Go to US Patent

TargetHistamine H4 receptor(Human)
C&C Research Laboratories

US Patent
LigandPNGBDBM294415(US9586959, Compound 93)
Affinity DataIC50: 53nMAssay Description:Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
C&C Research Laboratories

US Patent
LigandPNGBDBM294415(US9586959, Compound 93)
Affinity DataIC50: 1.00E+5nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in CHO-K1 cell membranes measured after 30 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed