BDBM294401 US9586959, Compound 66

SMILES CN1CCN(CC1)c1nc2ncc(Br)c(C)c2n2cnnc12

InChI Key InChIKey=MWPVFFBPURHQLC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 294401   

TargetHistamine H4 receptor(Human)
C&C Research Laboratories

US Patent
LigandPNGBDBM294401(US9586959, Compound 66)
Affinity DataIC50: 300nMpH: 7.5 T: 2°CAssay Description:In vitro profiling protein kinases was performed using the HotSpot assay platform. Briefly, specific kinase/substrate pairs along with required cofac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
Go to US Patent

TargetHistamine H4 receptor(Human)
C&C Research Laboratories

US Patent
LigandPNGBDBM294401(US9586959, Compound 66)
Affinity DataIC50: 300nMAssay Description:Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Sungkyunkwan University

Curated by ChEMBL
LigandPNGBDBM294401(US9586959, Compound 66)
Affinity DataIC50: 2.40E+4nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in CHO-K1 cell membranes measured after 30 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed