BDBM294016 1-(5-((4-((2S)-1-(1H-Tetrazol-5- yl)pent-3-yn-2- yl)phenoxy)methyl)benzo[b] thiophen-3-yl)-2-methylpiperidine::US10106553, Compound 48

SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(N4CCCCC4C)c3c2)cc1

InChI Key InChIKey=CMGIOJLBYQYPTK-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 294016   

TargetFree fatty acid receptor 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM294016(US10106553, Compound 48 | 1-(5-((4-((2S)-1-(1H-Tet...)
Affinity DataEC50:  83nMT: 2°CAssay Description:Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
Go to US Patent

LigandPNGBDBM294016(US10106553, Compound 48 | 1-(5-((4-((2S)-1-(1H-Tet...)
Affinity DataEC50:  21nMAssay Description:Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM294016(US10106553, Compound 48 | 1-(5-((4-((2S)-1-(1H-Tet...)
Affinity DataEC50:  83nMAssay Description:Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed