BDBM29397 tacrine-dihydropyridine hybrid (tacripyrine), 8

SMILES CCOC(=O)C1C(c2ccc(cc2)-c2ccccc2)c2c(N)c3CCCCc3nc2N=C1C

InChI Key InChIKey=CARWTONHZWZDHZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 29397   

TargetAcetylcholinesterase(Human)
Csic

LigandPNGBDBM29397(tacrine-dihydropyridine hybrid (tacripyrine), 8)
Affinity DataIC50: 71nMpH: 7.2 T: 2°CAssay Description:The inhibitory activity of the compounds towards hAChE was determined following the method of Ellman using AChE from human serum and acetylthiocholin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2009
Entry Details Article
PubMed
TargetCholinesterase(Human)
Csic

LigandPNGBDBM29397(tacrine-dihydropyridine hybrid (tacripyrine), 8)
Affinity DataIC50: 1.00E+5nMpH: 7.2 T: 2°CAssay Description:The inhibitory activity of the compounds towards BuChE was determined following the method of Ellman using BuChE from human serum and butyrylthiochol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2009
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Csic

LigandPNGBDBM29397(tacrine-dihydropyridine hybrid (tacripyrine), 8)
Affinity DataIC50: 90nMAssay Description:The inhibitory activity of the compounds towards hAChE was determined following the method of Ellman using AChE from human serum and acetylthiocholin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2009
Entry Details Article
PubMed