BDBM29394 CHEMBL220294::tacrine-dihydropyridine hybrid (tacripyrine), 5

SMILES CCOC(=O)C1C(c2cccc(c2)[N+]([O-])=O)c2c(N)c3CCCCc3nc2N=C1C

InChI Key InChIKey=QHRIUVOIKYNLOD-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 29394   

TargetAcetylcholinesterase(Human)
Csic

LigandPNGBDBM29394(CHEMBL220294 | tacrine-dihydropyridine hybrid (tac...)
Affinity DataIC50: 191nMpH: 7.2 T: 2°CAssay Description:The inhibitory activity of the compounds towards hAChE was determined following the method of Ellman using AChE from human serum and acetylthiocholin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2009
Entry Details Article
PubMed
TargetCholinesterase(Human)
Csic

LigandPNGBDBM29394(CHEMBL220294 | tacrine-dihydropyridine hybrid (tac...)
Affinity DataIC50: 1.00E+5nMpH: 7.2 T: 2°CAssay Description:The inhibitory activity of the compounds towards BuChE was determined following the method of Ellman using BuChE from human serum and butyrylthiochol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2009
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Csic

LigandPNGBDBM29394(CHEMBL220294 | tacrine-dihydropyridine hybrid (tac...)
Affinity DataIC50: 110nMAssay Description:The inhibitory activity of the compounds towards hAChE was determined following the method of Ellman using AChE from human serum and acetylthiocholin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2009
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csic

LigandPNGBDBM29394(CHEMBL220294 | tacrine-dihydropyridine hybrid (tac...)
Affinity DataIC50: 191nMAssay Description:Inhibition of human erythrocyte AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholinesterase(Human)
Csic

LigandPNGBDBM29394(CHEMBL220294 | tacrine-dihydropyridine hybrid (tac...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human serum BuChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Csic

LigandPNGBDBM29394(CHEMBL220294 | tacrine-dihydropyridine hybrid (tac...)
Affinity DataIC50: 110nMAssay Description:Inhibition of Electrophorus electricus AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed