BDBM293462 US10106527, Compound 66::US11548872, Compound 66::US20230286945, Compound 66::US9951048, Compound 66

SMILES CN1CC(C1)Oc1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1

InChI Key InChIKey=NFNIEYRGKUBMSG-UHFFFAOYSA-N

Data  7 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 293462   

LigandPNGBDBM293462(US10106527, Compound 66 | US9951048, Compound 66 |...)
Affinity DataEC50:  5.5nMT: 2°CAssay Description:Briefly, recombinant DYRK1A kinase, ATP and Ser/Thr peptide 18 were prepared in 1× Kinase buffer to final concentrations of 0.19 μg/mL, 30 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
Go to US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Samumed

US Patent
LigandPNGBDBM293462(US10106527, Compound 66 | US9951048, Compound 66 |...)
Affinity DataEC50:  2.71E+3nMT: 2°CAssay Description:Briefly, recombinant GSK3β kinase, ATP and Ser/Thr peptide 09 are prepared in 1× Kinase buffer to final concentrations of 0.04 μg/mL, 46 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
Go to US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Samumed

US Patent
LigandPNGBDBM293462(US10106527, Compound 66 | US9951048, Compound 66 |...)
Affinity DataEC50:  2.71E+3nMAssay Description:The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologiesa Div...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2020
Entry Details
Go to US Patent

LigandPNGBDBM293462(US10106527, Compound 66 | US9951048, Compound 66 |...)
Affinity DataEC50:  5.5nMAssay Description:The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies-a Divis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2020
Entry Details
Go to US Patent

LigandPNGBDBM293462(US10106527, Compound 66 | US9951048, Compound 66 |...)
Affinity DataEC50:  5.5nMAssay Description:The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies a Divis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
Go to US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Samumed

US Patent
LigandPNGBDBM293462(US10106527, Compound 66 | US9951048, Compound 66 |...)
Affinity DataEC50:  2.71E+3nMAssay Description:The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies a Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
Go to US Patent

LigandPNGBDBM293462(US10106527, Compound 66 | US9951048, Compound 66 |...)
Affinity DataEC50:  5.5nMAssay Description:The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies a Divis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
Go to US Patent