BDBM2926 4-(2-cyclopropylethynyl)-6-(trifluoromethoxy)-4-(trifluoromethyl)-2,4-dihydro-1H-3,1-benzoxazin-2-one::Efavirenz deriv. 4e

SMILES FC(F)(F)Oc1ccc2NC(=O)OC(C#CC3CC3)(c2c1)C(F)(F)F

InChI Key InChIKey=GBVDKAFHFXJKIV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 2926   

TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Dupont Pharmaceuticals

LigandPNGBDBM2926(4-(2-cyclopropylethynyl)-6-(trifluoromethoxy)-4-(t...)
Affinity DataIC50: 1.25E+3nMpH: 8.2 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2005
Entry Details Article
PubMed