BDBM292086 4-{2-[(3R)-3-aminopiperidine-1-carbonyl]- 5-[1-(2,2,2-trifluoroethyl)-1H-pyrazol-4- yl]-1,3-thiazol-4-yl}benzonitrile::US10100046, Example 21::US9902719, Example 21

SMILES N[C@@H]1CCCN(C1)C(=O)c1nc(c(s1)-c1cnn(CC(F)(F)F)c1)-c1ccc(cc1)C#N

InChI Key InChIKey=RSSUIMQJXWJYPA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 292086   

TargetLysine-specific histone demethylase 1A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM292086(US10100046, Example 21 | 4-{2-[(3R)-3-aminopiperid...)
Affinity DataIC50: 100nMAssay Description:The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM292086(US10100046, Example 21 | 4-{2-[(3R)-3-aminopiperid...)
Affinity DataIC50: 100nMT: 2°CAssay Description:This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent