BDBM292082 4-{2-[(3S)-3-aminopiperidine-1-carbonyl]- 5-(1-methyl-1H-1,3-benzodiazol-5-yl)-1,3- thiazol-4-yl}benzonitrile::US10100046, Example 17::US9902719, Example 17

SMILES Cn1cnc2cc(ccc12)-c1sc(nc1-c1ccc(cc1)C#N)C(=O)N1CCC[C@H](N)C1

InChI Key InChIKey=MGIZMNQJAOCVPN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 292082   

TargetLysine-specific histone demethylase 1A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM292082(US10100046, Example 17 | 4-{2-[(3S)-3-aminopiperid...)
Affinity DataIC50: 100nMT: 2°CAssay Description:This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
Go to US Patent

TargetLysine-specific histone demethylase 1A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM292082(US10100046, Example 17 | 4-{2-[(3S)-3-aminopiperid...)
Affinity DataIC50: 100nMAssay Description:The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent