BDBM291886 8-(2-(difluoromethyl)-6-methylpyridin-3-yl)-N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine::US11207325, Example 201::US9580437, Example 201

SMILES Cc1ccc(-c2cnc(NCc3c4CCOc4ccc3F)n3cnnc23)c(n1)C(F)F

InChI Key InChIKey=VFTBGQMPOGKNNW-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 291886   

LigandPNGBDBM291886(US9580437, Example 201 | 8-(2-(difluoromethyl)-6-m...)
Affinity DataIC50: 5.90nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291886(US9580437, Example 201 | 8-(2-(difluoromethyl)-6-m...)
Affinity DataIC50: 7.30nMpH: 8.0Assay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
Go to US Patent

LigandPNGBDBM291886(US9580437, Example 201 | 8-(2-(difluoromethyl)-6-m...)
Affinity DataIC50: 3.60nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
Go to US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandPNGBDBM291886(US9580437, Example 201 | 8-(2-(difluoromethyl)-6-m...)
Affinity DataIC50: 5.90nMAssay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
Go to US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandPNGBDBM291886(US9580437, Example 201 | 8-(2-(difluoromethyl)-6-m...)
Affinity DataIC50: 7.30nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
Go to US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandPNGBDBM291886(US9580437, Example 201 | 8-(2-(difluoromethyl)-6-m...)
Affinity DataIC50: 3.60nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
Go to US Patent