BDBM291852 8-(2,6-dimethylpyridin-3-yl)-N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine::US11207325, Example 167::US9580437, Example 167

SMILES Cc1ccc(c(C)n1)-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12

InChI Key InChIKey=GPOYFENWQYULOI-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 291852   

LigandPNGBDBM291852(US9580437, Example 167 | 8-(2,6-dimethylpyridin-3-...)
Affinity DataIC50: 3.30nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
Go to US Patent

LigandPNGBDBM291852(US9580437, Example 167 | 8-(2,6-dimethylpyridin-3-...)
Affinity DataIC50: 5.20nMpH: 8.0Assay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
Go to US Patent

LigandPNGBDBM291852(US9580437, Example 167 | 8-(2,6-dimethylpyridin-3-...)
Affinity DataIC50: 39.3nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
Go to US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandPNGBDBM291852(US9580437, Example 167 | 8-(2,6-dimethylpyridin-3-...)
Affinity DataIC50: 3.30nMAssay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
Go to US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandPNGBDBM291852(US9580437, Example 167 | 8-(2,6-dimethylpyridin-3-...)
Affinity DataIC50: 5.20nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
Go to US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandPNGBDBM291852(US9580437, Example 167 | 8-(2,6-dimethylpyridin-3-...)
Affinity DataIC50: 39.3nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
Go to US Patent

TargetCytochrome P450 2D6(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM291852(US9580437, Example 167 | 8-(2,6-dimethylpyridin-3-...)
Affinity DataIC50: 3.10E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate incubated for 10 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed