BDBM291816 5-(5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)amino)-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl)-N,N,4-trimethylpicolinamide::US11207325, Example 131::US9580437, Example 131

SMILES CN(C)C(=O)c1cc(C)c(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12

InChI Key InChIKey=AAJAVYJCVGGOEZ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 291816   

LigandPNGBDBM291816(US9580437, Example 131 | 5-(5-(((5-fluoro-2,3-dihy...)
Affinity DataIC50: 4nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
Go to US Patent

LigandPNGBDBM291816(US9580437, Example 131 | 5-(5-(((5-fluoro-2,3-dihy...)
Affinity DataIC50: 10.6nMpH: 8.0Assay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
Go to US Patent

LigandPNGBDBM291816(US9580437, Example 131 | 5-(5-(((5-fluoro-2,3-dihy...)
Affinity DataIC50: 3.30nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
Go to US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandPNGBDBM291816(US9580437, Example 131 | 5-(5-(((5-fluoro-2,3-dihy...)
Affinity DataIC50: 4nMAssay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
Go to US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandPNGBDBM291816(US9580437, Example 131 | 5-(5-(((5-fluoro-2,3-dihy...)
Affinity DataIC50: 10.6nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
Go to US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandPNGBDBM291816(US9580437, Example 131 | 5-(5-(((5-fluoro-2,3-dihy...)
Affinity DataIC50: 3.30nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
Go to US Patent