BDBM291630 1-(4-(((6-amino-5-(4-benzylphenyl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)prop-2-en-1-one ::US10413562, Compound A41::US9580449, Example A41

SMILES Nc1ncnc(NCC2CCN(CC2)C(=O)C=C)c1-c1ccc(Cc2ccccc2)cc1

InChI Key InChIKey=OUKHUMFQRXDYPK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 291630   

TargetTyrosine-protein kinase BTK(Human)
Merck Patent

US Patent
LigandPNGBDBM291630(1-(4-(((6-amino-5-(4-benzylphenyl)pyrimidin-4-yl)a...)
Affinity DataIC50: 100nMpH: 7.5 T: 2°CAssay Description:The following describes a microfluidic, off-chip mobility shift kinase assay used to measure inherent potency of compounds against BTK enzyme. Compou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Patent

US Patent
LigandPNGBDBM291630(1-(4-(((6-amino-5-(4-benzylphenyl)pyrimidin-4-yl)a...)
Affinity DataIC50: 100nMAssay Description:2.5× stocks of full-length human BTK (08-080) from CarnaBio USA, Inc., Natick, Mass., 1.6×ATP and appropriate kinKDR peptide substrate (FITC-AHA-EEPL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent