BDBM291358 (E)-1-(4-Methyl-piperazin-1-yl)-3-[4-morpholin-4-yl-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)-pyrido[3′,2′:4,5]furo[3,2-d]pyrimidin-8-yl]-propenone::US9580442, Example F

SMILES CN1CCN(CC1)C(=O)\C=C\c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1

InChI Key InChIKey=YSIZOVLWZSAZSZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 291358   

LigandPNGBDBM291358((E)-1-(4-Methyl-piperazin-1-yl)-3-[4-morpholin-4-y...)
Affinity DataIC50: 127nMAssay Description:PI3K Isoform using biochemical assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2019
Entry Details
Go to US Patent

LigandPNGBDBM291358((E)-1-(4-Methyl-piperazin-1-yl)-3-[4-morpholin-4-y...)
Affinity DataIC50: 109nMAssay Description:PI3K Isoform using biochemical assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2019
Entry Details
Go to US Patent

LigandPNGBDBM291358((E)-1-(4-Methyl-piperazin-1-yl)-3-[4-morpholin-4-y...)
Affinity DataIC50: 6nMAssay Description:PI3K Isoform using biochemical assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2019
Entry Details
Go to US Patent

LigandPNGBDBM291358((E)-1-(4-Methyl-piperazin-1-yl)-3-[4-morpholin-4-y...)
Affinity DataIC50: 269nMAssay Description:PI3K Isoform using biochemical assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2019
Entry Details
Go to US Patent