BDBM291323 US9580432, Example 54

SMILES Nc1ncnc2n(cc(C(=O)Nc3nc4cc(Cl)ccc4o3)c12)[C@@H]1CCN(C1)C(=O)\C=C\CN1CCCCC1

InChI Key InChIKey=WGEKMVIECKZQRS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 291323   

TargetTyrosine-protein kinase BTK(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM291323(US9580432, Example 54)
Affinity DataIC50: 1.44nMpH: 7.5Assay Description:With regard to the setting of the conditions for a method for measuring the inhibitory activity of a compound against BTK kinase activity in vitro, i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2019
Entry Details
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TargetEpidermal growth factor receptor(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM291323(US9580432, Example 54)
Affinity DataIC50: 37.1nMpH: 7.5 T: 2°CAssay Description:With regard to the setting of the conditions for a method for measuring the inhibitory activity of a compound against EGFR kinase activity in vitro, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2019
Entry Details
Go to US Patent