BDBM290889 1-[2-fluoro-4- (tetrahydro-2H- pyran-4-yl)phenyl]- 5-methoxy-3-(1- phenyl-1H-pyrazol- 5-yl)pyridazin- 4(1H)-one::US9579407, Example 00162

SMILES COc1cn(nc(-c2ccnn2-c2ccccc2)c1=O)-c1ccc(cc1F)C1CCOCC1

InChI Key InChIKey=PFQQSVKFDVADLG-UHFFFAOYSA-N

Data  4 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 290889   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM290889(US9579407, Example 00162 | 1-[2-fluoro-4- (tetrahy...)
Affinity DataIC50: 1nMpH: 7.4 T: 2°CAssay Description:Human PDE1A, 3A, 4D2, 5A1, 7B, 8A1, 9A2, and 11A4 enzymes were purchased from BPS Bioscience. Human PDE6AB enzyme was purchased from Scottish Biomedi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2019
Entry Details
Go to US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM290889(US9579407, Example 00162 | 1-[2-fluoro-4- (tetrahy...)
Affinity DataIC50: 0.770nMAssay Description:Inhibition of PDE10A (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
LigandPNGBDBM290889(US9579407, Example 00162 | 1-[2-fluoro-4- (tetrahy...)
Affinity DataKd:  12nMAssay Description:Binding affinity to PDE10A in rat brain caudate-putamen by saturation binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
LigandPNGBDBM290889(US9579407, Example 00162 | 1-[2-fluoro-4- (tetrahy...)
Affinity DataKd:  4.70nMAssay Description:Binding affinity to PDE10A in rat brain nucleus accumbens by saturation binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM290889(US9579407, Example 00162 | 1-[2-fluoro-4- (tetrahy...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of PDE10A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM290889(US9579407, Example 00162 | 1-[2-fluoro-4- (tetrahy...)
Affinity DataIC50: 0.770nMAssay Description:Inhibition of PDE10A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed