BDBM290851 2-((1R,2S)-2-aminocyclohexylamino)-4-(3-(benzo[d][1,3]dioxol-5-yl)phenylamino)pyrimidine-5-carboxamide::US9579320, Example 253

SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc(c2)-c2ccc3OCOc3c2)n1

InChI Key InChIKey=MLNFOQNYAHLMGQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 290851   

TargetTyrosine-protein kinase SYK(Human)
Portola Pharmaceuticals

US Patent
LigandPNGBDBM290851(US9579320, Example 253 | 2-((1R,2S)-2-aminocyclohe...)
Affinity DataIC50: 5.5nMpH: 7.5 T: 2°CAssay Description:Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2019
Entry Details
US Patent