BDBM290415 (3R,4S)-3-amino-4-(3-boronopropyl)-1-((6-chloro-1,2,3,4- tetrahydroisoquinolin-3-yl)methyl)pyrrolidine-3-carboxylic acid::US10098902, Example 51::US10603330, Example 51::US11389464, Example 51

SMILES N[C@]1(CN(CC2Cc3cc(Cl)ccc3CN2)C[C@@H]1CCCB(O)O)C(O)=O

InChI Key InChIKey=AJMFAHAHHSCGQI-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 290415   

TargetArginase-1(Human)
Mars

US Patent
LigandPNGBDBM290415((3R,4S)-3-amino-4-(3-boronopropyl)-1-((6-chloro-1,...)
Affinity DataIC50: 250nMpH: 7.4 T: 2°CAssay Description:Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
Go to US Patent

TargetArginase-2, mitochondrial(Human)
Mars

US Patent
LigandPNGBDBM290415((3R,4S)-3-amino-4-(3-boronopropyl)-1-((6-chloro-1,...)
Affinity DataIC50: 250nMpH: 7.4 T: 2°CAssay Description:Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
Go to US Patent

TargetArginase-1(Human)
Mars

US Patent
LigandPNGBDBM290415((3R,4S)-3-amino-4-(3-boronopropyl)-1-((6-chloro-1,...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetArginase-2, mitochondrial(Human)
Mars

US Patent
LigandPNGBDBM290415((3R,4S)-3-amino-4-(3-boronopropyl)-1-((6-chloro-1,...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetArginase-1(Human)
Mars

US Patent
LigandPNGBDBM290415((3R,4S)-3-amino-4-(3-boronopropyl)-1-((6-chloro-1,...)
Affinity DataIC50: 125nMAssay Description:Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
Go to US Patent

TargetArginase-2, mitochondrial(Human)
Mars

US Patent
LigandPNGBDBM290415((3R,4S)-3-amino-4-(3-boronopropyl)-1-((6-chloro-1,...)
Affinity DataIC50: 125nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
Go to US Patent