BDBM290325 (−)-trans-10-Chloro-4-(2-methylpiperidin-4-yl)pyrimido[1,2-b]indazol-2(1H)-one hydrochloride::US10098883, Example 68::US10668071, Example 101

SMILES CC1CC(CCN1)c1cc(=O)[nH]c2c3c(Cl)cccc3nn12

InChI Key InChIKey=GBMDIIOZEVMRKC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 290325   

TargetPlasminogen [101-181](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM290325(US10098883, Example 68 | (−)-trans-10-Chloro...)
Affinity DataIC50: 25nMpH: 7.0Assay Description:The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
Go to US Patent

TargetPlasminogen [101-181](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM290325(US10098883, Example 68 | (−)-trans-10-Chloro...)
Affinity DataIC50: 25nMAssay Description:The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
Go to US Patent

TargetPlasminogen [101-181](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM290325(US10098883, Example 68 | (−)-trans-10-Chloro...)
Affinity DataIC50: 35nMAssay Description:The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
Go to US Patent