BDBM289820 Methyl 4-(5-(1-(tert-butoxy)-1-oxo-3-phenylpropan-2-yl)-1H-imidazol-2-yl)-3-fluorothiophene-2-carboxylate::US10093683, Example 124

SMILES OC(=O)c1scc(c1F)-c1c[nH]c(n1)C(Cc1ccccc1)C(=O)N1CCC[C@@]2(C1)OC(=O)Nc1ccc(Cl)c(F)c21

InChI Key InChIKey=MXDQVXFGFBCFEV-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 289820   

TargetCoagulation factor XI(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM289820(Methyl 4-(5-(1-(tert-butoxy)-1-oxo-3-phenylpropan-...)
Affinity DataKi:  209nM ΔG°:  -9.11kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIa can be determined using a relevant purified serine...More data for this Ligand-Target Pair
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Date in BDB:
1/23/2019
Entry Details
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