BDBM289471 5-(2-isobutyl-1-(3- morpholinobicyclo- [1.1.1]pentan-1-yl)-1H- imidazol-4-yl)-3- (trifluoromethyl)- pyridin-2-amine::US10093664, Example 47

SMILES CC(C)Cc1nc(cn1C12CC(C1)(C2)N1CCOCC1)-c1cnc(N)c(c1)C(F)(F)F

InChI Key InChIKey=LLEUSGWCBPHXJX-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 289471   

TargetMitogen-activated protein kinase kinase kinase 12(Human)
The University of Texas System

US Patent
LigandPNGBDBM289471(US10093664, Example 47 | 5-(2-isobutyl-1-(3- morph...)
Affinity DataKd:  6nMAssay Description:The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2019
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase kinase kinase 12(Human)
The University of Texas System

US Patent
LigandPNGBDBM289471(US10093664, Example 47 | 5-(2-isobutyl-1-(3- morph...)
Affinity DataIC50: 655nMAssay Description:Inhibition of doxycycline-inducible human DLK transfected in HEK293 cells assessed as reduction in c-Jun phosphorylation at Ser63 residue incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed