BDBM289458 5-(2-(cyclopropyl- methyl)-1-(3-morpho- linobicyclo[1.1.1]- pentan-1-yl)-1H- imidazol-4-yl)-3- (trifluoromethyl)- pyridin-2-amine::US10093664, Example 35

SMILES Nc1ncc(cc1C(F)(F)F)-c1cn(c(CC2CC2)n1)C12CC(C1)(C2)N1CCOCC1

InChI Key InChIKey=WRFWYIDHBLUGOI-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 289458   

TargetMitogen-activated protein kinase kinase kinase 12(Human)
The University of Texas System

US Patent
LigandPNGBDBM289458(US10093664, Example 35 | 5-(2-(cyclopropyl- methyl...)
Affinity DataKd:  7.20nMAssay Description:The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2019
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase kinase kinase 12(Human)
The University of Texas System

US Patent
LigandPNGBDBM289458(US10093664, Example 35 | 5-(2-(cyclopropyl- methyl...)
Affinity DataIC50: 494nMAssay Description:Inhibition of doxycycline-inducible human DLK transfected in HEK293 cells assessed as reduction in c-Jun phosphorylation at Ser63 residue incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed