BDBM289421 5-(2-cyclopropyl-1-(3-morpholinobicyclo[1.1.1]pentan-1-yl)-1H-imidazol-4-yl)-3-(trifluoromethoxy)pyridin-2-amine::US10093664, Example 1

SMILES Nc1ncc(cc1OC(F)(F)F)-c1cn(c(n1)C1CC1)C12CC(C1)(C2)N1CCOCC1

InChI Key InChIKey=UZBGEWLDZRCMQZ-UHFFFAOYSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 289421   

TargetMitogen-activated protein kinase kinase kinase 12(Human)
The University of Texas System

US Patent
LigandPNGBDBM289421(US10093664, Example 1 | 5-(2-cyclopropyl-1-(3-morp...)
Affinity DataKd:  11.4nMAssay Description:The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2019
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase kinase kinase 12(Human)
The University of Texas System

US Patent
LigandPNGBDBM289421(US10093664, Example 1 | 5-(2-cyclopropyl-1-(3-morp...)
Affinity DataIC50: 262nMAssay Description:Inhibition of doxycycline-inducible human DLK transfected in HEK293 cells assessed as reduction in c-Jun phosphorylation at Ser63 residue incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
The University of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM289421(US10093664, Example 1 | 5-(2-cyclopropyl-1-(3-morp...)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of hERG expressed in CHO cells at -80 mV holding potential by QPatch automated electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed