BDBM289113 N-(4-(2H-tetrazol-5-yl)phenyl)-6-hydroxy-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide::US10093658, Compound Formula (IIb)

SMILES Oc1[nH]c(=S)[nH]c(=O)c1C(=O)Nc1ccc(cc1)-c1nnn[nH]1

InChI Key InChIKey=CRXIDCXAIWSZSG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 289113   

TargetSolute carrier family 22 member 12(Human)
Acquist

US Patent
LigandPNGBDBM289113(US10093658, Compound Formula (IIb) | N-(4-(2H-tetr...)
Affinity DataIC50: 1.47E+5nMAssay Description:URAT1 (SLC22A12) activity was evaluated in a cellular uptake assay using a 96-well plate with stably transfected URAT-1/CHO cells. 3H-orotate was use...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2019
Entry Details
Go to US Patent

TargetXanthine dehydrogenase/oxidase(Human)
Acquist

US Patent
LigandPNGBDBM289113(US10093658, Compound Formula (IIb) | N-(4-(2H-tetr...)
Affinity DataIC50: 390nMAssay Description:Xanthine oxidase inhibition was determined using a standard fluorescence-based assay for xanthine oxidase activity (McHale A, Grimes H, Coughlan M P:...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2019
Entry Details
Go to US Patent

TargetSolute carrier family 22 member 12(Human)
Acquist

US Patent
LigandPNGBDBM289113(US10093658, Compound Formula (IIb) | N-(4-(2H-tetr...)
Affinity DataIC50: 390nMAssay Description:Inhibition of URAT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Acquist

US Patent
LigandPNGBDBM289113(US10093658, Compound Formula (IIb) | N-(4-(2H-tetr...)
Affinity DataIC50: 1.47E+5nMAssay Description:Inhibition of URAT1 (unknown origin) assessed as decrease in uric acid levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed