BDBM289086 N-[(1 S)-2-[4-[2-[4-Amino-6-methyl-2-(trifluoromethyl)pyrimidin-5-yl]ethyl]-1-piperidyl]-1-methyl-2-oxo-ethyl]-2-methyl-pyrazole-3-carboxamide::US10093651, Example 2

SMILES C[C@H](NC(=O)c1ccnn1C)C(=O)N1CCC(CCc2c(C)nc(nc2N)C(F)(F)F)CC1

InChI Key InChIKey=FJLGBNQKFIHNGX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 289086   

TargetGhrelin O-acyltransferase(Human)
Eli Lilly

US Patent
LigandPNGBDBM289086(US10093651, Example 2 | N-[(1 S)-2-[4-[2-[4-Amino-...)
Affinity DataIC50: 69.5nMpH: 7.5Assay Description:Prepare test compounds in DMSO to make up a 0.2 mM stock solution. Serially dilute the stock solution in DMSO to obtain a ten-point dilution curve wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2019
Entry Details
Go to US Patent

TargetGhrelin O-acyltransferase(Human)
Eli Lilly

US Patent
LigandPNGBDBM289086(US10093651, Example 2 | N-[(1 S)-2-[4-[2-[4-Amino-...)
Affinity DataIC50: 70nMAssay Description:Inhibition of human His-tagged GOAT expressed in baculovirus infected Sf9 cell membrane using desacyl-ghrelin-biotin and octanoyl-CoA as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed