BDBM289003 US10093650, Example 14::US10093650, Example 16::US10329273, Example 14::US11479538, Example 14

SMILES Fc1cc(OCCCC(F)(F)F)ccc1[C@@]1(CC(c2ccn(CC3CC3)n2)=C(C(=O)N1)n1nn[nH]c1=O)C(F)(F)F

InChI Key InChIKey=VFFPVFKSCNJAMO-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 289003   

LigandPNGBDBM289003(US10093650, Example 16 | US10093650, Example 14 | ...)
Affinity DataIC50: 5nMpH: 7.4Assay Description:The MGAT enzyme reactions were performed in Corning FALCON 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2019
Entry Details
Go to US Patent

LigandPNGBDBM289003(US10093650, Example 16 | US10093650, Example 14 | ...)
Affinity DataIC50: 5nMpH: 7.4Assay Description:The MGAT enzyme reactions were performed in Corning FALCON 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2019
Entry Details
Go to US Patent

LigandPNGBDBM289003(US10093650, Example 16 | US10093650, Example 14 | ...)
Affinity DataIC50: 5nMAssay Description:The MGAT enzyme reactions were performed in Corning FALCON 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
Go to US Patent

Target2-acylglycerol O-acyltransferase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM289003(US10093650, Example 16 | US10093650, Example 14 | ...)
Affinity DataIC50: 5nMAssay Description:The MGAT enzyme reactions were performed in Corning FALCON 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
Go to US Patent

LigandPNGBDBM289003(US10093650, Example 16 | US10093650, Example 14 | ...)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of human MGAT2 using 2-oleoylglycerol and oleoyl-coenzyme A as substrate by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM289003(US10093650, Example 16 | US10093650, Example 14 | ...)
Affinity DataIC50: 20nMAssay Description:Inhibition of mouse MGAT2 using 2-oleoylglycerol and oleoyl-coenzyme A as substrate by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM289003(US10093650, Example 16 | US10093650, Example 14 | ...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant human DGAT2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM289003(US10093650, Example 16 | US10093650, Example 14 | ...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant human DGAT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM289003(US10093650, Example 16 | US10093650, Example 14 | ...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant human MGAT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM289003(US10093650, Example 16 | US10093650, Example 14 | ...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant human AWAT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM289003(US10093650, Example 16 | US10093650, Example 14 | ...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant human AWAT2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM289003(US10093650, Example 16 | US10093650, Example 14 | ...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant human DC3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM289003(US10093650, Example 16 | US10093650, Example 14 | ...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant human ACAT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetAcetyl-CoA acetyltransferase, cytosolic(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM289003(US10093650, Example 16 | US10093650, Example 14 | ...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant human ACAT2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM289003(US10093650, Example 16 | US10093650, Example 14 | ...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of recombinant human MGAT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed